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KMID : 1130620060020020107
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Journal of Clinical Neurology
2006 Volume.2 No. 2 p.107 ~ p.112
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Diffusion Weighted Imaging Findings in the Acute Lateral Medullary Infarction
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Lee Jung-Hwa
Choi Byung-Ok
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Abstract
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Background and Purpose: Negative findings on diffusion-weighted imaging (DWI) does not exclude the possibility of brainstem infarction, particularly in the acute stage of medullary lesion. Our aim was to investigate the false-negative rate of DWI in patients with acute lateral medullary infarction.
Methods: We applied DWI to 26 patients with a clinical diagnosis of lateral medullary infarction within 72 h of the onset. We assessed relationships between initial DWI findings and time-to-MRI (the time between onset of symptoms and initial DWI), number of clinical symptoms and signs, and final lesion volume.
Results: There were 8 cases (31%) of false negatives in the initial DWI results. The occurrence of false- negative DWI findings decreased significantly as the time-to-MRI increased (P=0.014). However, the false-negative rate was not significantly correlated with the number of clinical symptoms and signs or the final lesion volume.
Conclusions: The diagnosis of lateral medullary infarction should not be ruled out on the basis of early negative DWI. To confirm the lesion, follow-up DWI or further MRI should be performed in cases with early negative DWI results
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KEYWORD
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Lateral medullary infarction, False-negative DWI, Time-to-MRI
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